Indication predictions table for compound XXX

LEGEND: Is the compound:target association unknown and new?
YES NO
Target: Mnemonic Name Target: Gene Name pK Average Similarity with SAFAN-ISP fragments Average Similarity with SAFAN-ISP compounds Expected Correlation with in Vitro Data Indications Side Effects
B0FL73 7.159 0.699 0.626 0,88
ADRB3 ADRB3 6.574 0.869 0.636 0,56 Endocrine, nutritional and metabolic diseases Atrial fibrillation* Cardiovascular disorder* Diseases of the circulatory system* Diseases of the digestive system* Diseases of the eye and adnexa* Diseases of the respiratory system* Hypertension* Neoplasms* Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
KCNH2 KCNH2 6.302 0.677 0.675 0,79 Diseases of the circulatory system Atrial fibrillation* Hypertension
NMDZ1 GRIN1 6.242 0.611 0.726 0,72 Diseases of the nervous system* Diseases of the skin and subcutaneous tissue
ADRB1 ADRB1 6.147 0.859 1.000 0,7 Atrial fibrillation* Cardiovascular disorder* Diseases of the circulatory system* Diseases of the digestive system* Diseases of the eye and adnexa* Diseases of the respiratory system* Endocrine, nutritional and metabolic diseases* Hypertension* Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SMN SMN1 5.317 0.970 0.525 ***
LMBL1 L3MBTL1 5.314 0.701 0.502 0,77
ADRB2 ADRB2 5.255 0.835 1.000 0,71 Diseases of the respiratory system Atrial fibrillation* Cardiovascular disorder* Connective tissue disorder* Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism* Diseases of the circulatory system* Diseases of the digestive system* Diseases of the eye and adnexa* Diseases of the nervous system* Diseases of the skin and subcutaneous tissue* Endocrine, nutritional and metabolic diseases* Hypertension* Injury, poisoning and certain other consequences of external causes* Neoplasms
AMPC_nomam AMPC 5.02 0.723 0.553 0,61
MK01 MAPK1 4.999 0.967 0.562 0,68 Neoplasms Diseases of the circulatory system* Diseases of the digestive system* Diseases of the musculoskeletal system and connective tissue* Diseases of the respiratory system* Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
RORG RORC 4.96 0.746 0.551 0,61
HCD2 HSD17B10 4.713 0.924 0.489 0,66

Rare Diseases Prediction Table for compound XXX

Target: Mnemonic Name Target: Gene Name pK Average Similarity with SAFAN-ISP fragments Average Similarity with SAFAN-ISP compounds Expected Correlation with in Vitro Data Indications Side Effects
ADRB3 ADRB3 6.574 0.869 0.636 0,56 Short fifth metacarpals - insulin resistance Atrial fibrillation* Cardiovascular disorder* Diseases of the circulatory system* Diseases of the digestive system* Diseases of the eye and adnexa* Diseases of the respiratory system* Hypertension* Neoplasms* Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
KCNH2 KCNH2 6.302 0.677 0.675 0,79 Brugada syndrome* Romano-Ward syndrome Atrial fibrillation* Hypertension